Covid 19: what will the end of the pandemic look like? – The world

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  3. The trail of a universal anti-coronavirus vaccineThe world
  4. Covid-19: the promising results of an mRNA vaccine capable of combating all variantsNeozOne
  5. See full coverage on Google News

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Loss of smell in COVID-19: cause identified – healing practice

Mechanisms of short and long-term anosmia in COVID-19 deciphered

Loss of the sense of smell, or anosmia, is one of the most commonly reported symptoms of COVID-19. However, it has so far remained unclear which mechanisms the coronavirus SARS-CoV-2 uses to cause the loss of smell. This has now been clarified in a current study.

Researchers from the Institut Pasteur, the CNRS, the Inserm, the Université de Paris and the Paris Public Hospital Network (AP-HP) have investigated the mechanisms that can lead to short-term and long-term anosmia when infected with SARS-CoV-2. Persistent inflammation of the epithelium and the olfactory nervous system are the main causes. The corresponding study results were published in the journal “Science Translational Medicine”

Many people with non-respiratory symptoms

Although COVID-19, caused by the SARS-CoV-2 virus, is primarily a respiratory disease, many sufferers also show non-respiratory symptoms. This includes a sudden loss of smell in people. However, the specific cause for this remained unclear.

For example, it was suspected that temporary edema of the olfactory fissures inhibits the flow of air that transports odor molecules to the olfactory neurons (the well-known feeling of a stuffy nose that occurs with a cold) triggers the loss of smell, the researchers explain.

Mechanisms of COVID-19-related anosmia analyzed

In the current study, the research team has now analyzed the causal mechanisms of COVID-19-related anosmia based on examinations of COVID-19 sufferers and supplementary tests in an animal model. According to this, SARS-CoV-2 infects sensory neurons and causes inflammation of the epithelium and the olfactory nervous system. In addition, persistent inflammation of the epithelium and the olfactory nervous system as well as a permanent presence of the virus in the olfactory epithelium can be detected in those affected with long-term anosmia.

Furthermore, in the course of the SARS-CoV-2 infection, a chronological sequence of the following points is involved in the anosmia:

  1. Cilia carried by sensory neurons are lost. These cilia enable sensory neurons to receive olfactory molecules;
  2. Virus spread in sensory neurons;
  3. Disruption of the integrity of the olfactory epithelium (sense organ), associated with apoptosis (cell death);
  4. Virus spread in the olfactory bulb, which is the first cerebral relay station in the olfactory system;
  5. Inflammation and viral RNA in different regions of the brain.

“We have observed that SARS-CoV-2 not only infects the sensory neurons, but also the olfactory nerve and the olfactory nerve centers in the brain,” explains Pierre-Marie Lledo from the Pasteur Institute.

“According to our results, the loss of olfactory sense in COVID-19 can persist for several months in some patients, and this persistence of clinical symptoms can be attributed to the persistence of the virus and the inflammation in the olfactory mucosa,” added Marc Lecuit, head of the department for infection biology at the Pasteur Institute.

Gateway to the brain

In addition, an important finding of the study is that the infection of the olfactory neurons could represent a gateway for the viruses to the brain, which is also a possible explanation for why some sufferers have various psychological (anxiety disorders, depression) and neurological complaints (cognitive impairments, susceptibility) for the development of a neurodegenerative disease).

Effects on the test

Another unexpected result of the study was that “nasopharyngeal swabs with standard RT-qPCR can test negative, even if the virus is still present in the back of the nasal cavity, in the olfactory epithelium,” reports the research team. This must be taken into account when testing those affected with loss of smell. (fp)

Author and source information

This text complies with the requirements of specialist medical literature, medical guidelines and current studies and has been checked by medical professionals.

Swell:

  • Guilherme Dias de Melo, Françoise Lazarini, Sylvain Levallois, Charlotte Hautefort, Vincent Michel, Florence Larrous, Benjamin Verillaud, Caroline Aparicio, Sebastien Wagner, Gilles Gheusi, Lauriane Kergoat, Etienne Kornobis, Flora Donati, Thomas Cokelaer, Rémi Hervochon, Yoann Madec, Emmanuel Roze, Dominique Salmon, Hervé Bourhy, Marc Lecuit, Pierre-Marie Lledo: COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters; in: Science Translational Medicine (veröffentlicht 03.05.2021), sciencemag.org
  • Institut Pasteur: COVID-19: Discovery of the mechanisms of short- and long-term anosmia (veröffentlicht 12.05.2021), pasteur.fr

Important NOTE:
This article is for general guidance only and is not intended to be used for self-diagnosis or self-treatment. He can not substitute a visit at the doctor.

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Covid doctors, without rest or licenses 15 months after the pandemic – Politics

Mexico City. After more than a year of forced marches to combat the Covid-19 pandemic, a large part of the health personnel in Mexico have not received rest licenses to regain strength or take care of their physical and emotional health. And so they continue.

This is the result, to a large extent, of the reduced number of doctors and nurses in this service, but also of the work habit of not admitting fatigue, as well as of the working conditions, such as temporary hiring and without benefits. In this way, the exhaustion in this sector is ignored in the official reports, although the accounts of many show it.

Health workers consulted by The Day and data from the largest health institutions in the country establish that practically none of its members have requested a work license to alleviate the fatigue derived from treating Covid patients, or in short, there are no detailed records in this regard.

The information “equals zero”

When responding to requests for information from this newspaper, various government agencies indicated that since the beginning of the Covid-19 pandemic in Mexico and until the first quarter of this year, no worker requested or received work disability leave due to stress, emotional exhaustion or other causes related to your mental health. And in other cases, the impossibility of disclosing these data was argued.

The Psychiatric Care Services of the Ministry of Health, for example, pointed out that the information on the subject is “confidential, since it concerns only the owner of the personal data” in question, and its dissemination would cause harm to those involved by making them identifiable .

The Mexican Institute of Social Security (IMSS) – which enabled 290 of its medical units throughout the country and more than 16 thousand beds for Covid patients – pointed out that within its databases “the degree of detail requested is not available.” about the personnel who would have requested leave due to emotional exhaustion.

In the case of the Institute of Social Security and Services for State Workers (ISSSTE), which had at least 37 hospitals to face the pandemic, it was answered that “it does not have the required information”, because it did not have it disaggregated by sex, age , position and place of residence of the workers.

And the Institute of Health for Wellbeing (Insabi), which hired more than 10,000 health workers in the framework of the pandemic, said that the response to the request for information is “equal to zero”, and the Ministry of Defense Nacional – which had 98 health facilities against Covid – responded that “no documentary evidence was found” on the subject.

Only the Secretary of the Navy reported that so far in the pandemic, four of its doctors received licenses: two women and a man for “emotional exhaustion” and a woman for “generalized anxiety disorder, due to the loss of a family member.”

“We don’t deserve to be so stressed out all the time.”

But when consulted by this newspaper, workers from various health institutions pointed out that although there is a need to request permits to regain strength in the care of Covid patients, a large part of the staff receives a negative response or simply does not request them so as not to be criticized. or suffer retaliation.

A nurse who works in a hospital of the Ministry of Health – who requested anonymity – indicated in an interview that, after receiving the second dose of the Covid vaccine and having presented adverse reactions, she was authorized two days of disability, although some of his colleagues estimated that the side effects were actually signs of chronic fatigue.

“We already want the comrades who are on leave to return (because they are vulnerable to the virus), because there are no personnel and they are not giving permits. The only thing they tell you is ‘there are no staff, we can’t give you days,’ “he lamented.

This same lack of sufficient workers, he said, means that those who are active in the service have to cover a large number of tasks. “You finish one thing and you join another and another. Due to stress, there comes a time when you feel like you are short of breath ”.

The pulmonologist Jennifer Escobar agrees that caring for Covid patients is a task that physically and emotionally exhausts medical personnel, among other things because they are between 6 and 8 hours a day wearing personal protective equipment that makes them heat up, but that they cannot take off even to drink water or go to the bathroom.

“It is practically a sauna and you certainly sweat and become dehydrated. Add to that having to deal with the feelings of five or 10 intensive care patients who are feeling overwhelmed. All this affects the psyche of doctors, nurses and quartermaster personnel ”.

Despite this, a large part of the health personnel do not request rest licenses “for fear of being seen badly. The doctor has greater flexibility and they can reduce hours and work groups, but the nurses are there constantly, on their full time. They are the great workhorse and they have not been given the recognition they deserve ”.

In the country, laments the specialist, “there is a culture of not complaining. It is like a silence that one suddenly expresses with his partner, but there is no real support. A year of accumulated burnout has already passed and we have to learn to live with this and move on. Meditation and yoga would be good options, because we don’t deserve to be so stressed all the time. We have families that shouldn’t pay for the broken dishes and nobody sees that ”.

A job that makes you sick

But the lack of a work culture where rest is given importance is not the only reason why many doctors in Covid areas have worked non-stop. A large part of them, having temporary contracts, simply do not have the possibility to ask for a break.

“Throughout this year I have had my vacation periods, and that obviously helps you, but I am concerned about the Insabi doctors and nurses. There was not enough staff (in my hospital), because many went on leave, and people were hired who are super happy because they are paid very well, but they live in anxiety that they are going to fire them and have not had a vacation at all the year ”, explained a pulmonologist who preferred to reserve her identity.

By enduring such a long period without rest, he affirmed, “the people of Insabi are very tired and fed up, and the problem is that many hospitals are working that way. They console themselves with the good pay – compared to what they are used to – but physically and emotionally they are exhausted. The need for their salary is what makes them stand up ”.

Although stress and fatigue are part of the training and life of healthcare personnel since their professional start, the Covid-19 pandemic has exacerbated this situation to a point where healthcare workers can make more mistakes. with their patients or perceive their work as a burden that makes them sick, experts warned.

Dr. Benjamín Guerrero López, head of the Department of Psychiatry and Mental Health of the Faculty of Medicine of the National Autonomous University of Mexico, pointed out in an interview that, although the figures vary according to each particular study, it is estimated that at least 50 percent of specialist physicians already have occupational burnout problems.

This situation, which is not different between those who work in the public or private sector, are the result of the many hours of work and preparation that this work requires from the university and that, added to other conditions of life, can lead to problems anxiety, depression or alcohol and other substance abuse.

“Health personnel live depressed, tired and angry, and the care they provide is exhausting. A doctor with burnout is definitely more susceptible to making mistakes, but must supplement the family income with highly demanding and unrewarding services, ”he pointed out.

One of the teachings of the pandemic, according to Guerrero, is that “the model with which we have been training, in which the staff does not get sick and must remain stoic all the time, has already been exceeded, because it also has fear, he gets depressed and wears out, and that prevents him from providing quality care ”.

Human beings “cannot work endlessly or face all the burdens that come our way. We have mechanisms to cope, but after a certain degree, overload leads to disease, “he warned.

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VACCINATION ORDER FALLS: Appointment? Which corona vaccine? A family doctor explains what you need to know – WELT news channel

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CORONA PANDEMIC: New record! And the Covid-19 vaccination rate in Germany continues to pick up – WELT news channel

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Not wearing a mask will depend on vaccines and less transmission, says WHO

The waiver of the use of a mask should only be considered when there is a good vaccination coverage against covid-19 and a reduced transmission of the SARS-CoV-2 virus, the World Health Organization (WHO) warned this Friday.

“Countries should take into account vaccine coverage and the local incidence rate [do vírus que provoca a covid-19] before deciding to withdraw these measures, “said Michael Ryan, director of WHO’s emergency program, at a press conference.

The United States announced on Thursday that it will end the mandatory use of facial masks for vaccinated people, including in some closed environments, due to the favorable evolution of the fight against the covid-19 pandemic, a change welcomed by President Joe Biden.

The Centers for Disease Control and Prevention (CDC) revised their guidelines for fully vaccinated people, allowing them to stop wearing masks outdoors in crowds and in most indoor environments.

However, the use of masks in crowded closed environments, such as buses, airplanes, hospitals or prisons, is still required.

At today’s press conference, held digitally from the WHO headquarters in Geneva, Michael Ryan recalled that vaccines against covid-19 protect against the most serious disease, but there is still “no great proof of the ability to a vaccinated person infects other people “.

In view of this, countries that intend to remove the obligation to wear a mask, should only do so “taking into account the intensity of transmission in this area and, at the same time, the level of vaccination coverage”, said the WHO responsible for the programs. emergency, without specifically referring to the United States.

For epidemiologist Maria Van Kerkhove, who is responsible for the WHO’s response to covid-19, the decision of national authorities to waive the use of a mask must always be assessed “within the context” of each country’s epidemiology, but also on the level of vaccination achieved.

“We are not yet out of danger. There are still many uncertainties due to the variants and we must do everything possible to prevent further infections and save lives,” warned the epidemiologist.

The covid-19 pandemic caused at least 3,333,603 deaths worldwide, resulting from more than 160.3 million cases of infection, according to a report made by the French agency AFP.

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New York Offers Free Burgers to Encourage Vaccination | The World | DW

New York City and popular fast food chain Shake Shack announced that they will be offering free burgers and fries to encourage citizens to get vaccinated against COVID-19.

The mayor of the Big Apple, Bill de Blasio, presented the promotion by eating a portion in the middle of a press conference and at a more suitable time for breakfast, in an image that soon circulated in local media and social networks.

“Mmm, vaccination,” declared De Blasio after taking a bite of a hamburger in his peculiar attempt to tempt New Yorkers to one of the points installed throughout the city to administer doses of the serum.

“There are a lot of people who are ready to get vaccinated, they just haven’t. They need a little additional incentive,” said the mayor, who in recent days has announced several strategies to make it easier for all citizens, New Yorkers and abroad, to get get the vaccine.

Within these efforts, Shake Shack, born in New York, will offer a voucher for a hamburger to those who get vaccinated at one of the mobile points throughout the city over the next few days.

For those who have already received the picket in the arm, the restaurant chain offers free fries along with the purchase of a sandwich just by presenting the vaccination card.

Incentives of all kinds to encourage citizens to get vaccinated have become widespread in recent weeks in the United States, as the rate of vaccination has dropped, not due to lack of doses, but due to lack of arms to administer them.

The country has the arduous task of convincing the undecided in a race against time until July 4, Independence Day “of the virus”, in the words of President Joe Biden, when the goal is that 70% of adults have received at least one dose and that some 160 million people are immunized.

ee (efe/twitter/larepública)

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USA: Vaccinated people are allowed to take off masks – Biden: “great day for America” ​​- guide

“A great day for America!” This is how US President Joe Biden described the day on which the USA largely lifted the mask requirement for vaccinated people!

▶ ︎ Anyone who is fully vaccinated against the virus will no longer have to wear a mask outdoors and indoors, as the CDC said on Thursday. Distance rules are also repealed. However, there are exceptions in public transport and at airports and train stations.

“Anyone who is fully vaccinated can participate in indoor and outdoor activities in large or small groups without wearing a mask or keeping a distance from others,” said CDC chief Rochelle Walensky. “When you are fully vaccinated, you can start doing the things you stopped doing because of the pandemic.”

▶︎ According to the CDC, fully vaccinated means: A person is considered fully vaccinated two weeks after their second vaccination dose, or two weeks after their first vaccination dose if only one injection is required, as is the case with the vaccine from the US pharmaceutical company Johnson & Johnson.

The CDC guidelines are basically recommendations. However, they are followed by a large number of states.

US President Joe Biden spoke of a “milestone” in the fight against the pandemic. The relaxation of the corona restrictions can be traced back to the “extraordinary success” of the nationwide vaccination campaign. Since he took office 114 days ago, 250 million vaccine doses have been administered, said the president in the rose garden of the White House. The US would lead the world with it.

At the same time, Biden again called on everyone to get vaccinated – and to wear a mask until they are completely vaccinated: “Please protect yourself until we reach the finish line.”

In the United States, around 154 million people have received at least one dose of vaccine, and more than 117 million people are fully vaccinated. Of the adult population, just under 59 percent received at least one dose. Biden has announced the goal of increasing this proportion to 70 percent by the national holiday on July 4th.

On Thursday, the United States also began vaccinating children and adolescents between the ages of twelve and 15 across the country. After the vaccine from Biontech and Pfizer for this age group was approved by the FDA, the CDC issued a corresponding vaccination recommendation on Wednesday evening.

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Covid, the defense of Ranieri Guerra on the pandemic in a memory given to the prosecutors – Il Tempo

Francesco Storace

Forty pages to get rid of very heavy accusations, related to the failure to fight Covid in Italy. A detailed defense is the one that the lawyer Roberto De Vita prepared on behalf of Ranieri Guerra, number 2 of the World Health Organization, and which is to the attention of the Bergamo magistrates who have investigated his client. The 40-page memoir attempts to counter the accusations, including those in the media, following a terrible tragedy. Starting first of all from the pandemic plan in force since 2006. The defense of Ranieri Guerra denies that there has been inattention to the theme: “It was reviewed annually”. To the magistrates, Guerra claims to have stated verbatim that “as long as I was general manager, the plan was reviewed annually and confirmed in validity”. More: it is stated that in 2017, at the end of his commitment to the Ministry of Health as director general, Guerra proposed “to review the plan after the publication of the WHO guidelines completed that year”. And that therefore he “cannot be responsible for what happened after 2017”. On this point, it is evident that Guerra aims, if anything, to verify what happened after the end of his mandate at the ministry: “If you want to ascertain any conduct constituting a crime (…) you should, if necessary, check what has been done following of the publication of the 2017 guidelines and further additions thereafter “.

Tens of thousands of deaths that could have been saved, the researcher's denounce book

The same ministry of health in April 2020 – it is always the defense that speaks – considers the 2006 plan to be in force. “The information reported in the email communication sent on 15 April 2020 by the Director of Office V – Prevention of communicable diseases and international prophylaxis of the Ministry of Health, dr. Maraglino to the Deputy Minister dr. Sileri and the General Manager dr. D’Amario on the “Pandemic Plan”: in this letter, in fact, the deeds, actions and general instruments adopted by the Ministry and still in force are listed, including the 2006 influenza pandemic plan, revised and updated and indicated as ” still in force “. It does not end here. The regions are called into question for the “distribution of roles, tasks and functions pursuant to the provisions of art. 117 of the Constitution “, the famous title V. But also the national civil protection:” In this regard it is useful to highlight how in January 2018 there was also a legislative change of great importance that attributes, defining them, broad powers and responsibilities to the Department of Civil Protection “. The Ministry of Health, Guerra defends himself, “becomes only an operational tool of the Civil Protection Department, which instead assumes the role of top coordination and control”.

Remove it now, it's an emergency.  WHO in trouble over the email on the Covid report and pressure from China

Finally, the delicate question of the “WHO report” on Italian healthcare with respect to Covid, published and then removed. On that report the work of the lawyer. De Vita report tells the magistrates that he limited himself to making corrections on the merits, without intervening in any way either in the withdrawal of the same or in the subsequent events (“concerning exclusively Zambon and his office in Copenhagen but in any case not Guerra”). Indeed, it is reiterated in the defensive memory when the researcher Francesco Zambon “says he will publish, the same Guerra only asks that his name be removed”. A last passage of the document produced by the defense of Ranieri Guerra is that concerning the famous whatsapp chats with Silvio Brusaferro, with the suspicion that they could have been reconstructed in a “fragmented and decontextualized” way. Obviously, it will be up to the magistrates of Bergamo to decide how to proceed, hoping if anything – on our part – a swift work to finally guarantee elements of clarity to public opinion.

The e-mail scandal of Guerra a Speranza: Minister, that report will do damage

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Coronavirus live ticker: +++ 02:42 Thousands of retailers want to sue for higher aid payments +++

Coronavirus-Liveticker
+++ 02:42 Thousands of retailers want to sue for higher aid payments +++

Thousands of retailers want to get more generous state corona aid through legal action. According to a survey by the German Trade Association (HDE), around 10,000 companies have applied for state aid in November and December, which is primarily intended for the catering industry. Shops that have been closed for months, however, have no entitlement to it, but are referred to the narrower fixed cost subsidy, said HDE boss Stefan Genth of “Welt am Sonntag”. “That is a clear unequal treatment compared to gastronomy”. A sample complaint has been prepared.

+++ 01:27 Stiko: More vaccination will be necessary next year +++
The Standing Vaccination Commission (Stiko) expects that German citizens will have to be vaccinated against the corona virus again in the coming year. “The virus will not leave us again. The current corona vaccinations will therefore not be the last,” said Stiko chairman Thomas Mertens to the newspapers of the Funke media group. The Germans would have to be prepared for the fact that everyone might have to refresh their vaccination protection next year. The manufacturers say they are already working on modified vaccines that are supposed to be effective against currently known mutants.

+++ 00:43 students in the USA should continue to wear a mask +++
Students in the United States should continue to wear masks in class and keep safe distances. The CDC recommends this. The agency has recorded 582,263 coronavirus-related deaths and more than 32.7 million infections. To date, 270.8 million vaccine doses have been administered in the United States. The vaccination of children and adolescents aged twelve and over has only just begun.

+++ 23:25 Brazil vaccinates athletes for Tokyo +++
Brazil’s government begins vaccinating athletes and other delegation members for the Tokyo Olympic and Paralympic Games. Health Minister Marcelo Queiroga had previously announced that Brazil would receive 4,050 doses of vaccine from Biontech / Pfizer and another 8,000 from Sinovac. Around 1800 people are to be vaccinated for Tokyo, the remaining vaccine doses are to go to the public health system SUS. President Jair Bolsonaro played down the corona virus from the start. If he gets infected with the virus as an athlete, he’ll just get a “little flu,” he said. Meanwhile, the right-wing populist also doubts the point of vaccinations.

+++ 22:30 The model Taiwan tightened restrictions +++
After a surge in infections in Taiwan, the East Pacific Island authorities tightened contact restrictions in the capital Taipei and the surrounding area. The government raised the alert for the capital region after health officials registered 180 new domestic infections. The day before, only 29 new infections had been reported. Taiwan is internationally regarded as a role model in the fight against the corona virus. Since the beginning of the pandemic, only around 1,500 infections have been detected there, twelve people died in connection with Corona.

+++ 22:04 Scholz wants to use solos for pandemic financing +++
Federal Finance Minister Olaf Scholz is in favor of using the income from the solidarity surcharge to combat the financial consequences of the pandemic. “Let’s keep the remaining solidarity surcharge to refinance the costs of the corona pandemic,” the SPD candidate for chancellor wrote on Twitter. The SPD chairman Norbert Walter-Borjans suggested this back in December. The retention of the “Solis” in its restricted form since January is part of the SPD election program.

+++ 21:41 Almost all federal states report declining numbers +++
In most federal states, the number of cases is clearly declining. With the exception of Berlin with currently 455 new infections, the daily increases are far below the average number of cases over the past seven days. North Rhine-Westphalia (1685), Baden-Württemberg (1400) and Bavaria (1189) have four-digit numbers. The fewest new cases are reported by Hamburg (65), Bremen (48) and Saarland (42).

+++ 21:13 Berlusconi released from hospital +++
Former Italian Prime Minister Silvio Berlusconi has been released from hospital after several days of treatment. The 84-year-old is eager to return to “full activity”, explains the deputy head of Berlusconi’s Forza Italia party, Antonio Tajani. Berlusconi was admitted to the San Raffaele hospital in Milan on Tuesday. According to AFP information, the admission was related to the long-term consequences of his corona infection. The former prime minister was infected with the virus in 2020. It was the fourth time this year that Berlusconi was hospitalized.

+++ 20:41 Current data situation in Germany: 7723 new cases reported +++
The number of reported coronavirus infections in Germany has risen to 3,587,594. As can be seen from the information from the state authorities evaluated by ntv.de, 7723 new cases were added. The daily increase is around 6500 cases below the level of Saturday last week. This corresponds to a decrease of 45.8 percent. However, a public holiday preceded the current weekend on Thursday. According to the RKI, the number of reports should therefore be lower than usual.

There has also been a decrease in the number of reported deaths. Last Saturday, the federal states reported 186 deaths, today there are 141. This brings the total number of deaths to 86,044. Around 221,400 people are currently infected.

The infection rate (R value) is given by the Robert Koch Institute (RKI) as 0.85 (previous day: 0.80). The 7-day R-value is currently 0.84 (previous day: 0.87). According to the Divi Register, 4089 Covid-19 patients are currently being treated in intensive care in Germany, 2590 of whom are ventilated. Around 4,300 intensive care beds are currently still available in the German clinics.

You can find more information about the most important corona data here read up.

You can read all previous developments here.

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