One vaccine should protect for years

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Coronavirus is always evolving

The rapid development of several vaccines against the coronavirus gives hope. Nevertheless, these first vaccines must be further developed so that they also protect against corona mutations in the long term. Scientists have now started this work.

+++ You can find all current information on the coronavirus in our live ticker on RTL.de +++

Effect of previous vaccines

It is not yet clear how long the protection of the individual vaccines actually works. It is therefore not yet possible to say when the vaccines will have to be further developed. Albert Bourla, head of Pfizer, has already announced that an annual refresh will probably be necessary. The vaccines to date mainly work by stimulating the production of antibodies. The production of T cells is only marginal.

We have listed the differences between the vaccines approved so far for you here.

First vaccines in clinical trials

However, some researchers are now focusing on a different way to develop a permanently effective vaccine. With their vaccines, they try to stimulate T cells in particular – that part of the immune response that focuses on finding and eliminating cells that are already infected, not the virus itself, reports ntv.de.

The French company OSE Immunotherapeutics is currently having the first such vaccine clinically tested. “It could protect for several years,” says CEO Alexis Peyroles. These new vaccines will be ready for the market in the coming year at the earliest.

Criticism: Virus could become immune to vaccines

There is also criticism of these super vaccines. Some researchers believe this could mutate the virus to the point where it develops a variant that is immune to any vaccine.

AUDIO NOW Podcast recommendation on Corona

10 facts about the corona vaccination

For many people, the first corona vaccination appointment is getting closer and closer. But many questions are still open and new ones are added every day. When can I make an appointment? Who can I contact for a vaccination appointment? Can I choose my active substance myself and do I have to follow the AHA rules after the vaccination? Should I get vaccinated even though I already had Corona? We answer these and other questions here in our web story.

TVNOW documentary “Children in the Corona Crisis”

The coronavirus has kept the world in suspense for more than a year and is one of the greatest challenges of our time. How are our children doing in the pandemic and how are z. B. lockdown restrictions affecting them? In the TVNOW documentary “Children in the Corona Crisis”, children and young people tell what their greatest challenges are.

LRA

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Is COVID-19 a completely different disease than previously thought? – healing practice

What kind of disease is COVID-19 really?

COVID-19 appears to be a vascular disease and not a type of respiratory disease caused by a cold virus. The new findings help explain the multitude of seemingly unrelated complications of COVID-19 and could potentially enable the development of new therapies.

The characteristic spike proteins of SARS-CoV-2 not only help the virus infect potential hosts, they also play a key role in the disease itself. The experts at the University of California San Diego and the Salk Institute for Biological Studies found that COVID-19 is actually a vascular disease and demonstrated how the SARS-CoV-2 virus damages and attacks the vascular system at the cellular level. The research group published the associated study in the English-language journal “Circulation Research”.

Is COVID-19 a respiratory disease?

“Many people think that COVID-19 is a respiratory disease, but COVID-19 is actually a vascular disease. This could explain why some people have strokes and why some people have problems in other parts of the body. What they have in common is that they all have a vascular basis, ”reports study author Professor Uri Manor of the Salk Institute for Biological Studies.

While the results themselves aren’t entirely surprising, the work provides clear confirmation and detailed explanation of the mechanism by which the spike protein first damages vascular cells, the team explains.

Does spike protein damage vascular endothelial cells?

There is a growing consensus that SARS-CoV-2 attacks the vasculature, but how exactly this happens was previously unknown. Researchers working on other coronaviruses have long suspected that the spike protein contributes to damage to vascular endothelial cells. The current investigation now documents this process for the first time.

Spike protein alone can cause illness

During their investigation, the experts generated a type of pseudovirus which was surrounded by the classic crown of the spike proteins of SARS-CoV-2, but which did not contain any actual virus. Exposure to this pseudovirus resulted in damage to the lungs and arteries in an animal model. This proves that the spike protein alone is enough to cause the disease. The tissue samples showed inflammation in the endothelial cells that line the walls of the pulmonary arteries, the experts said.

Damage to mitochondria from spike protein alone

The team then replicated this process in the lab, exposing healthy endothelial cells (that line arteries) to the spike protein. It was found that the spike protein damages the cells by binding ACE2. This binding disrupted the molecular signaling of ACE2 to the mitochondria (organelles that produce energy for the cells), causing the mitochondria to be damaged and fragmented, the team explains.

Previous studies have shown a similar effect when cells have been exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein alone, they explain Professionals.

“If you remove the replication abilities of the virus, it still has a great damaging effect on the vascular cells, simply because of its ability to bind to that ACE2 receptor, the S-protein receptor, now known thanks to COVID. Further studies with mutated spike proteins will also provide new insights into the infectivity and severity of the mutated SARS CoV-2 viruses, ”adds Professor Uri Manor in a press release from the Salk Institute for Biological Studies.

Next, the team plans to investigate in more detail the mechanism by which the disrupted ACE2 protein damages the mitochondria and causes them to change their shape.

Author and source information

This text complies with the requirements of specialist medical literature, medical guidelines and current studies and has been checked by medical professionals.

Swell:

  • Yuyang Lei , Jiao Zhang , Cara R. Schiavon , Ming He , Lili Chen et al.: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2, in Circulation Research (veröffentlicht 31.03.2021), Circulation Research
  • Salk Institute for Biological Studies: The novel coronavirus’ spike protein plays additional key role in illness (veröffentlicht 30.04.2021), Salk Institute for Biological Studies

Important NOTE:
This article is for general guidance only and is not intended to be used for self-diagnosis or self-treatment. He can not substitute a visit at the doctor.

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Genetic material could be the reason for persistent Corona positive

Although the infection was a long time ago, some people test positive in corona PCR tests. A new study finds a possible explanation in the genome.

the essentials in brief

  • Some people keep getting positive results from the Corona PCR test.
  • This although the infection was a long time ago and there was no new one.
  • Researchers have now found a possible answer in the human genome.

In some people, the Corona-PCR test shows a positive result, even though the infection was a long time ago. And there is no new one. Researchers have a possible explanation for this.

A team of researchers has apparently found isolated small pieces of genetic material of the Sars-CoV-2 coronavirus in the genetic material of human cells. They pose no danger, the group explains in the “Proceedings” of the US National Academy of Sciences (“PNAS”).

Such built-in tiny fragments cannot lead to whole virus particles and also cannot trigger renewed infection. This is what the researchers around Rudolf Jaenisch from the Whitehead Institute for Biomedical Research in Cambridge (Massachusetts, USA) write.

The discovery could explain why some people test positive in the PCR test after their corona infection.

Virus Rna in the genome

The researchers’ results are supported by a study published in the journal “PLOS ONE”. This was carried out by a group led by Ithan Peltan from the University of Utah in Salt Lake City.

They examined patients who retested positive with a PCR test 60 days or more after a positive corona test. In around 90 percent of the cases, there was no Sars-CoV-2 infection despite a positive PCR test, so there was no renewed infection.

The human genome consists of so-called DNA (deoxyribonucleic acid). In the case of RNA viruses, which also include Sars-CoV-2, the genetic information consists of RNA (ribonucleic acid).

In order for viral RNA to get into human genome, it has to be transcribed into DNA by biological tools. And then be built into the genome.

The researchers also found interesting results in the “PNAS” study: in rare cases, genetic fragments of the coronavirus were found in the genome of people who had previously been infected with the pathogen.

They also tried to simulate the integration in laboratory tests. Accordingly, they succeeded in introducing short fragments of the virus genome into the genome of cultured human cell lines.

No health risk

A researcher not involved in the study stated that the authors had specifically helped with the integration. Oliver Weichenrieder from the Max Planck Institute for Developmental Biology in Tübingen said they used laboratory cells that produce a particularly large amount of so-called Line1 reverse transcriptase.

In general, this enzyme also integrates viral RNA from time to time. “The proof that Sars-CoV-2-RNA fragments can also be artificially integrated in this way is therefore not really surprising.”

In the opinion of the experts, the phenomenon does not play a role when using RNA vaccines. In normal human cells, the decisive enzyme activity is extremely low, explained virus expert Joachim Denner from the Robert Koch Institute (RKI). The probability that a Sars-CoV-2-RNA vaccine will be fragmentarily transcribed into DNA and incorporated into the cell genome is therefore almost zero.

Weichenrieder emphasized: “The occasional integration of Sars-CoV-2-RNA into the DNA of some human infected cells is certainly academically interesting. And should definitely be further scientifically investigated. But I cannot see any danger to human health from this. “

More on the subject:

Denner Salt Coronavirus study


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Covid-19 is not a respiratory disease

“Covid is much more of a vascular disease”

“This important study from California proves what has long been suspected. Covid is much more of a vascular disease than a lung disease.”, SPD health expert Karl Lauterbach posts on Twitter. He is referring to a study from California that was published a few days ago. Researchers have found that corona is not a respiratory disease at all.

+++ You can find all current information on the coronavirus in our live ticker on RTL.de +++

Spike protein plays a key role

The “spines” of the coronavirus, the so-called spike proteins of its shell, are now probably known to most. They are mainly used when it comes to the particular risk of infection from the virus. But a new study now shows that these special proteins not only play a key role in transmission, but also in the Covid 19 disease itself, which is triggered by the virus.

From the point of view of the researchers, Covid-19 is actually a vascular disease

In the paper published in the journal “Circulation Research”, researchers from the USA and China show that Sars-CoV-2 damages and attacks the vascular system at the cellular level. From their point of view, Covid-19 is therefore a vascular disease. In her opinion, this is the only way to explain the large number of apparently unrelated complications after corona infections. RTL medical expert Dr. Christoph Specht in the video above.

“A lot of people think of it as a respiratory disease, but it really is a vascular disease,” said Uri Manor, one of the study’s authors, in a statement from the Salk Institute for Biological Studies. “That could explain why some people have strokes and why some people have problems in other parts of the body. The commonality between them is that they all have vascular bases.” The researchers followed up on this trace in the blood vessels.

READ TIP: This happens in our cells after a vaccination

Spike protein damages cells by binding the enzyme ACE2

For their study, they created a “pseudovirus” that was surrounded by the classic Sars-CoV-2 crown made of spike proteins, but that did not contain an actual virus. The pseudovirus already caused damage to the lungs and arteries in animal models – proof that the spike protein alone was sufficient to cause disease. Tissue samples also showed inflammation in the cells that line the walls of the pulmonary artery.

READ TIP: First real photo: This is what the coronavirus really looks like

The team repeated this process in the laboratory and exposed healthy endothelial cells to the spike protein. It was found that the spike protein damaged the cells by binding the ACE2 enzyme. This enzyme is mainly produced by cells in the lungs, where it can act as the entry point for the virus on the cell surface. ACE2 is also produced in soluble form and is distributed in human serum.

Its physiological function is to break down the blood pressure-increasing hormone angiotensin I. The damaged bond disrupted the molecular signal transmission from ACE2 to mitochondria, the organelles that generate energy for cells. This damaged and fragmented the mitochondria. If the damage becomes too great, the cell dies.

READ TIP: ACE2 enzyme – that’s why men get COVID-19 more often

Great harmful effect on the vascular cells even without the ability to reproduce

Previous studies showed a similar effect when cells were exposed to Sars-CoV-2. However, this is the first study to show that the damage already occurs when cells are merely exposed to the spike protein. Even without the virus’ ability to replicate, “it still has a major damaging effect on vascular cells,” said Manor. The reason for this is the ability to bind to this ACE2 receptor, the spike protein receptor.

READ TIP: New study – coronavirus takes advantage of our immune system

With further studies on mutated spike proteins, the scientists now want to gain new knowledge about the infectivity and severity of mutated coronaviruses. They also hope to next investigate the mechanism by which the destroyed ACE2 protein damages the mitochondria and causes them to change shape.

ntv.de, SBA

AUDIO NOW Podcast recommendation on Corona

10 facts about the corona vaccination

For many people, the first corona vaccination appointment is getting closer and closer. But many questions are still open and new ones are added every day. When can I make an appointment? Who can I contact for a vaccination appointment? Can I choose my active substance myself and do I have to follow the AHA rules after the vaccination? Should I get vaccinated even though I already had Corona? We answer these and other questions here in our web story.

TVNOW documentary “Children in the Corona Crisis”

The coronavirus has kept the world in suspense for more than a year and is one of the greatest challenges of our time. How are our children doing in the pandemic and how are z. B. lockdown restrictions affecting them? In the TVNOW documentary “Children in the Corona Crisis”, children and young people tell what their greatest challenges are.

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Health distributes 2,190 ambulances equipped on main roads during Eid Al-Fitr

Hala Zayed, Minister of Health and Population, announced a comprehensive medical insurance plan during the blessed Eid Al-Fitr period, in all governorates of the Republic, as part of the Ministry’s concern for the health and safety of citizens.

Dr. Khaled Mujahid, Assistant Minister of Health and Population for Information and Awareness and the official spokesperson for the Ministry, explained that the medical insurance plan includes payment of 2,190 equipped ambulances to be distributed on roads, highways, and main squares in the governorates, in addition to 11 river ambulance launches, indicating that the degree has been raised. Preparing for the utmost in all public, central and quality hospitals, and intensifying the presence of medical teams, including doctors, technicians, and nursing in hospital emergency departments, in addition to convening a crisis and emergency room at the Ministry’s general office to follow up the implementation of the medical insurance plan around the clock.

Mujahid emphasized the availability of sufficient stocks of medicines and medical and preventive supplies in hospitals in all governorates of the Republic, pointing to the availability of sufficient stocks of blood and its derivatives from all factions in the blood centers and banks affiliated with the Ministry in all governorates of the Republic, as the blood balances amounted to 94 thousand blood bags from different factions, and 17 One thousand plasma bags, referring to the continuous coordination and communication between the ambulance and health affairs directorates in the governorates, in addition to allocating teams for rapid deployment with the aim of rapid intervention in the event of any emergency or accident.

Mujahid called on citizens again to adhere to preventive and precautionary measures in conjunction with state measures to address the emerging corona virus, stressing the importance of adhering to wearing a mask, washing hands frequently, maintaining social distancing, and being in well-ventilated places, in addition to the need to reduce home visits and family gatherings in order to preserve The health of all family members, and care must be taken to follow a healthy diet, which strengthens the immune system, such as eating healthy foods rich in vitamins and natural fibers.

Mujahid noted that the community communication teams continue to intensify awareness-raising and health education campaigns for citizens in the various governorates at the level of the Republic, to spread awareness of precautionary and preventive measures for the Corona virus in conjunction with holidays and religious events, pointing to the need to go to the nearest hospital belonging to the Ministry of Health and Population in the governorate in case of feeling any Symptoms of Corona virus disease, or calling the hotline (105) to receive inquiries, and he also stressed the importance of periodic follow-up of home isolation patients to their health status by sending text messages with the word “isolation” to (1440).

Within the framework of the ministry’s plan for Eid al-Fitr preparations, Mujahid revealed that 223 tons and 897 kilograms of various foods and drinks were seized and executed due to their unfit for human consumption, during several inspection campaigns launched by the General Administration for Food Control on food establishments in all governorates of the Republic, in the context of intensifying campaigns Inspecting food establishments and taking all precautionary measures to ensure that food is suitable for human consumption and that it conforms to standard specifications, in order to ensure the safety of citizens.

For his part, Dr. Alaa Eid, Head of Preventive Medicine Sector, explained that 2747 food establishments were passed through to ensure that they meet the health requirements that must be met, indicating that 6648 samples of various foods have been withdrawn to determine their suitability for human consumption, and sent for analysis by the central and regional laboratories of the Ministry of Health. And residents, in addition to closing 416 food establishments for violating health requirements, and 2,643 reports were drawn up regarding violations that were detected during traffic, in accordance with the laws and ministerial decisions in this regard, stressing the continuation of inspection campaigns and monitoring of food establishments and markets, to ensure food safety and take all legal measures towards Violators in order to preserve the public health of citizens.

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Christian Drosten: Anyone who does not get vaccinated against Corona will become infected

© 1&1 Mail & Media/spot on news

Updated May 12, 2021, 9:18 a.m.

  • Christian Drosten recently spread optimism about the pandemic: “Summer can be quite good in Germany.”
  • In the latest episode of the “Coronavirus Update” he is already looking towards autumn and beyond.

You can find more about the coronavirus here

The virologist Christian Drosten estimates that the population in Germany will become immune to the coronavirus in about the next one and a half years. This will happen through vaccination or natural infection, said the scientist from Charité Berlin in the podcast “Coronavirus Update” (NDR-Info) on Tuesday. “This virus will become endemic, it will not go away. And anyone who now actively decides against being vaccinated, for example, will inevitably become infected.” Nothing could be done about it, as the measures would be reduced further and further over time.

Thereafter, the virus circulates in the population, for example unnoticed in the throat of vaccinated people and in smaller children who cannot yet be vaccinated. “The virus will spread undetected under a blanket of immune protection. And then it always hits people who are not immunized by a vaccination, who are fully receptive.” According to the virologist, there will still be COVID-19 cases in intensive care units in the coming winter. He believes that “those who actively decide against the vaccination must know that they are also actively opting for the natural infection. Without any evaluation,” said Drosten. It is a free choice.

Drosten sees no problem in the previous second vaccination with Astrazeneca

The head of Charité Virology had already said a few days ago on ZDF that he was confident for the time from June, because the vaccinations would have a noticeable effect for the first time in that month. “Summer can be quite good in Germany.” On Tuesday, he said that the situation would consolidate significantly if the young, very mobile people were also vaccinated. These have special functions in the virus transmission network. The virologist is quite relaxed about travel by newly vaccinated people: He currently sees no reason for quarantine on their return.

The virologist does not consider the possibility of having the two Astrazeneca vaccine doses to be administered four weeks apart in consultation with the doctor and then going on vacation, as he said. Compared to the twelve weeks recommended by the Standing Vaccination Commission, the impact and sustainability of the second dose are not as strong. But it’s still better than just having one dose. You can get vaccinated again in a few months.

Virologist expects re-vaccination

Drosten confirmed that he was already assuming that certain groups should be generously vaccinated against COVID-19 in the autumn, depending on age and risk. He intends to combine this with immunization against flu. “Someone who is at risk for influenza is also at risk for Covid.” It is to be feared that the next flu wave will be severe if one does not counteract with vaccinations, said Drosten. The background is that the influenza wave failed in the past autumn and winter in Germany, but also in other countries – also because of the measures taken against the pandemic.

The Indian Corona variant, which is now classified by Great Britain and the World Health Organization (WHO) as worrying, currently has no particular advantage in Germany from Drosten’s point of view. The population here is not yet as immunized as in Great Britain. The mutant is a little less affected by vaccination and immunity.

According to the virologist, the conditions for the spread of such variants are likely to change in Germany as vaccination progresses in autumn. It is not possible to predict which variant will then prevail or which will appear again. The mutants then no longer brought a new pandemic, “but we will also be protected against these viruses in terms of symptoms,” said Drosten. There will also be booster vaccines.

“The virus has a bit more fitness, but that doesn’t mean at all that it poses a huge immediate threat to us,” said Drosten about the variant from India. “We can inoculate against it. We are no longer as defenseless as last year at this time.” (dpa / awa)
© dpa

The vaccinations are progressing – the more, the greater the desire of the rest of those willing to be vaccinated to finally be on the line. Thousands try tricks or even false information.

Teaserbild: © picture alliance/dpa/Michael Kappeler

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CORONA VACCINATION FOR YOUNG PEOPLE: "Urgent! Then especially older people have to stand back!" – WORLD news channel

  1. CORONA VACCINATION FOR YOUNG PEOPLE: “Urgently required! Then especially older people have to stand back!”WORLD news channel
  2. Biontech vaccine for children in EU from May?SALZBURG24
  3. USA approves Biontech / Pfizer vaccine for 12 to 15 year oldsVOL.AT
  4. Austria and Bavaria open the border for short visits and shopping, 870 new infectionsderStandard.at
  5. Biontech makes billions in profitsoe24
  6. See “More on Topic” in Google News

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Better a low immune response than none | Health city Berlin

Researchers from Israel report that MS patients taking fingolimod and ocrelizumab do not have an adequate vaccination response. Experts from the Competence Network Multiple Sclerosis do not share the concerns. They advise vaccination.

A publication from Israel is causing a sensation in neurological circles. Anat Achiron’s group recently published a study according to which there is no or insufficient vaccination response to fingolimod and ocrelizumab. This is justified by the ELISA measurement with antibodies against the recombinantly produced spike protein of SARS CoV 2. The publication also gives extensive treatment and conversion recommendations for patients with multiple sclerosis.

Competence Network MS strongly recommends vaccination

The Disease-Related Competence Network Multiple Sclerosis (KKMS) does not share the concern that, particularly in the case of treatment with S1P modulators, there may be no vaccination protection.

“In the vaccination recommendation of the KKNMS, we have already stated that with the vaccines against SARS CoV 2 currently on the market – as with other vaccinations – a reduced immune response could occur with certain drugs, but are generally strongly advised to vaccinate against SARS CoV2 becomes ”, says KKNMS board member Prof. Zipp, director of the clinic and polyclinic for neurology, Mainz. “Even reduced protection is important and better than no protection,” says Zipp.

France recommends a third vaccination for MS patients

As far as the flu vaccination is concerned, it is known that the immune reaction is reduced under both ocrelizumab and S1P modulators, but is definitely present. For this reason, certain intervals between the last or first (before the initiation of a new) drug administration are currently recommended for all vaccinations and for SARS CoV2 immunization. In France, it is already recommended that transplant recipients and immunosuppressed patients receive a third dose of an mRNA vaccine 3 to 4 weeks after the second.

Immune response more diverse than measurable antibodies

“Basically, we now know that the immune response to a SARS CoV 2 infection can be varied, antibodies as well as B and T cells are involved,” says KKNMS spokesman Prof Wiendl. According to the findings to date, there was a rather low correlation between antibody and cellular immune responses. The measurement of antibody responses after vaccination does not fully depict the competence of the immune response against SARS CoV2. The neurologist emphasizes that the clinical vaccination response was not investigated in the Israeli work.

The KKNMS does not recommend an active change in therapy or a delayed start of therapy in patients with highly active MS due to concerns about the vaccination or vaccination response.

Foto: © Adobe Stock / Prostock-studio

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World Health classifies the Corona strain in India as “ of concern ”

The World Health Organization (WHO) described (WHOThe Indian Coronavirus strain as a global concern, after data indicating that the Indian strain is known as B.1.617.2 – More contagious than previous versions of the virus, according to what was published by the British newspaper “Daily Mail”. Thus, the Indian Corona strain is the fourth mutation of the Corona virus, which the World Health Organization classifies as “of global concern”, after the strains that appeared in Kent, South Africa and Brazil.

“We classify the Indian strain as a global cause of a different kind of concern. There is some information available that indicates increased transmissibility,” said Maria Van Kerkhove, WHO’s chief technical officer on Corona.

Public Health England classifies this strain as a variable of concern, but the US Centers for Disease Control and Prevention (CDC)CDCShe described it as an “interesting variable.”

This strain, often described as a “double mutant”, carries mutations to the two parts of the thorn protein that helps the Corona virus attach to human cells.

Was split up B.1.617 To three related subspecies, together they account for nearly 75% of cases in India, and just over 1% of cases in the United States.

But the most worrisome variant, Type 2, does not contain a specific mutation thought to help the virus evade the antibodies.

Screenshot 2021-05-11 102616
Soumya Swaminathan is a Senior Scientist at the World Health Organization

The World Health Organization said the predominant strain of B.1.617 It was first identified in India in December, although an earlier version was discovered in October 2020.

The variant has already spread to other countries, and many countries have moved to cut off or restrict movements from India, US health officials described B.1.617 It was declared an “interesting strain” last week, due to its worrisome mutations.

However the CDC’s variable tracking website (CDCIncludes data on B.1.617 , Indicating that it accounts for a fraction of a percentage of all cases in the United States.

Studies are underway in India to examine the transmissibility of the variant, the severity of the disease it causes, and the antibody response, said Soumya Swaminathan, WHO chief scientist.

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